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Target Snapshot

CHEMBL2354313 Target Snapshot

Peptidoglycan D,D-transpeptidase MrdA · SINGLE PROTEIN · Bacteria

0Compounds
0Assays
0Approved Drugs
0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Peptidoglycan D,D-transpeptidase MrdA shows approved-linked disease relevance led by bacterial disease. 1 more disease program remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P0AD65. Start with bacterial disease, then reuse UniProt P0AD65 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with bacterial disease, then reuse UniProt P0AD65 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 2 linked drugs
Open source guide
Disease program
bacterial disease

Peptidoglycan D,D-transpeptidase MrdA shows approved-linked disease relevance led by bacterial disease. 1 more disease program remain visible in the same review block. 2 linked drugs remain visible in the same block.

Start review with bacterial disease because it currently carries approved-linked support. Linked drugs include AMDINOCILLIN, AMDINOCILLIN PIVOXIL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 2 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Peptidoglycan D,D-transpeptidase MrdA as ChEMBL target CHEMBL2354313, mapped to UniProt P0AD65. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Peptidoglycan D,D-transpeptidase MrdA
SINGLE PROTEIN · Bacteria
As of 2026-09-13
ChEMBL target ID
CHEMBL2354313
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P0AD65
Peptidoglycan D,D-transpeptidase MrdA
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Peptidoglycan D,D-transpeptidase MrdA is the right protein anchor across sources, using UniProt P0AD65 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why bacterial disease is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPeptidoglycan D,D-transpeptidase MrdA
UniProt AccessionP0AD65
Component TypeProtein
Sequence Length633 aa

Peptidoglycan D,D-transpeptidase MrdA

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Peptidoglycan D,D-transpeptidase MrdA, mapped to UniProt P0AD65. Sequence length is 633 aa.

Mapped IDP0AD65
Review namePeptidoglycan D,D-transpeptidase MrdA
OrganismBacteria
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Peptidoglycan D,D-transpeptidase MrdA shows approved-linked disease relevance led by bacterial disease. 1 more disease program remain visible in the same review block.

Approved-linked Approved
bacterial disease
2 linked drugs · 2 direct · 2 efficacy
Linked drugAMDINOCILLIN
Linked drugAMDINOCILLIN PIVOXIL
Approved-linked Approved
urinary tract infection
1 linked drug · 1 direct · 1 efficacy
Linked drugAMDINOCILLIN PIVOXIL
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with bacterial disease because it currently carries approved-linked support. Linked drugs include AMDINOCILLIN, AMDINOCILLIN PIVOXIL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasebacterial disease
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Source · ChEMBL 36 via Core Engine