Hypoxanthine-guanine phosphoribosyltransferase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P00492. Use UniProt P00492 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P00492 as the stable identity anchor, then attach disease evidence before program review.
Hypoxanthine-guanine phosphoribosyltransferase
Review this target as Hypoxanthine-guanine phosphoribosyltransferase, mapped to UniProt P00492. Sequence length is 218 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Hypoxanthine-guanine phosphoribosyltransferase as ChEMBL target CHEMBL2360, mapped to UniProt P00492. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Hypoxanthine-guanine phosphoribosyltransferase is the right protein anchor across sources, using UniProt P00492 as the stable mapping.
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| Preferred Name | Hypoxanthine-guanine phosphoribosyltransferase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P00492 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Hypoxanthine-guanine phosphoribosyltransferase |
| UniProt Accession | P00492 |
| Component Type | Protein |
| Sequence Length | 218 aa |
Hypoxanthine-guanine phosphoribosyltransferase
Review this target as Hypoxanthine-guanine phosphoribosyltransferase, mapped to UniProt P00492. Sequence length is 218 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4282830 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL5184028 | 8.89 | Ki | 1.3 | Preclinical |
| CHEMBL1233663 | 8.74 | Ki | 1.8 | Preclinical |
| CHEMBL4290716 | 8.52 | Ki | 3.0 | Preclinical |
| CHEMBL5573402 | 8.52 | Ki | 3.0 | Preclinical |
| CHEMBL1233603 | 8.34 | Ki | 4.6 | Preclinical |
| CHEMBL4086362 | 8.22 | Ki | 6.0 | Preclinical |
| CHEMBL5207635 | 8.22 | Ki | 6.0 | Preclinical |
| CHEMBL4277753 | 8.1 | Ki | 8.0 | Preclinical |
| CHEMBL4285691 | 8.1 | Ki | 8.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 48 | 160 | 6.0 |
| assay format | 3 | 4 | 6.0 |
| cell-based format | 1 | 5 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 12 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 3 | 9 | 6.0 |