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Target Snapshot

CHEMBL2362992 Target Snapshot

Amidophosphoribosyltransferase · SINGLE PROTEIN · Homo sapiens

1Compounds
2Assays
0Approved Drugs
0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Amidophosphoribosyltransferase shows approved-linked disease relevance led by acute lymphoblastic leukemia. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q06203. Start with acute lymphoblastic leukemia, then reuse UniProt Q06203 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with acute lymphoblastic leukemia, then reuse UniProt Q06203 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 2 linked drugs
Open source guide
Disease program
acute lymphoblastic leukemia

Amidophosphoribosyltransferase shows approved-linked disease relevance led by acute lymphoblastic leukemia. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.

Start review with acute lymphoblastic leukemia because it currently carries approved-linked support. Linked drugs include AZATHIOPRINE, MERCAPTOPURINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 2 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Amidophosphoribosyltransferase as ChEMBL target CHEMBL2362992, mapped to UniProt Q06203. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Amidophosphoribosyltransferase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2362992
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q06203
Amidophosphoribosyltransferase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Amidophosphoribosyltransferase is the right protein anchor across sources, using UniProt Q06203 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why acute lymphoblastic leukemia is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAmidophosphoribosyltransferase
UniProt AccessionQ06203
Component TypeProtein
Sequence Length517 aa

Amidophosphoribosyltransferase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Amidophosphoribosyltransferase, mapped to UniProt Q06203. Sequence length is 517 aa.

Mapped IDQ06203
Review nameAmidophosphoribosyltransferase
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Amidophosphoribosyltransferase shows approved-linked disease relevance led by acute lymphoblastic leukemia. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
acute lymphoblastic leukemia
2 linked drugs · 2 direct · 2 efficacy
Linked drugAZATHIOPRINE
Linked drugMERCAPTOPURINE
Approved-linked Approved
childhood acute lymphoblastic leukemia
1 linked drug · 1 direct · 1 efficacy
Linked drugMERCAPTOPURINE
Approved-linked Approved
Delayed Graft Function
1 linked drug · 1 direct · 1 efficacy
Linked drugAZATHIOPRINE
Approved-linked Approved
immune system disease
1 linked drug · 1 direct · 1 efficacy
Linked drugAZATHIOPRINE
Approved-linked Approved
lymphoblastic lymphoma
1 linked drug · 1 direct · 1 efficacy
Linked drugMERCAPTOPURINE
Approved-linked Approved
lymphoid leukemia
1 linked drug · 1 direct · 1 efficacy
Linked drugMERCAPTOPURINE
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with acute lymphoblastic leukemia because it currently carries approved-linked support. Linked drugs include AZATHIOPRINE, MERCAPTOPURINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseacute lymphoblastic leukemia
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
0
Tested Compounds
1
Assay Types
Binding — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine