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Target Snapshot

CHEMBL2362994 Target Snapshot

DNA polymerase/reverse transcriptase · SINGLE PROTEIN · Hepatitis B virus

0Compounds
0Assays
0Approved Drugs
0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

DNA polymerase/reverse transcriptase shows approved-linked disease relevance led by chronic hepatitis B virus infection. 5 more disease programs remain visible in the same review block. 9 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q9IF40. Start with chronic hepatitis B virus infection, then reuse UniProt Q9IF40 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with chronic hepatitis B virus infection, then reuse UniProt Q9IF40 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 9 linked drugs
Open source guide
Disease program
chronic hepatitis B virus infection

DNA polymerase/reverse transcriptase shows approved-linked disease relevance led by chronic hepatitis B virus infection. 5 more disease programs remain visible in the same review block. 9 linked drugs remain visible in the same block.

Start review with chronic hepatitis B virus infection because it currently carries approved-linked support. Linked drugs include ADEFOVIR, ADEFOVIR DIPIVOXIL, ELVUCITABINE, ENTECAVIR. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 9 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats DNA polymerase/reverse transcriptase as ChEMBL target CHEMBL2362994, mapped to UniProt Q9IF40. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
DNA polymerase/reverse transcriptase
SINGLE PROTEIN · Hepatitis B virus
As of 2026-09-13
ChEMBL target ID
CHEMBL2362994
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q9IF40
Protein P
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether DNA polymerase/reverse transcriptase is the right protein anchor across sources, using UniProt Q9IF40 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why chronic hepatitis B virus infection is currently framed as approved-linked support. It currently carries 9 linked drugs in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProtein P
UniProt AccessionQ9IF40
Component TypeProtein
Sequence Length832 aa

Protein P

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as DNA polymerase/reverse transcriptase, mapped to UniProt Q9IF40. ChEMBL maps the protein component as Protein P. Sequence length is 832 aa.

Mapped IDQ9IF40
Review nameDNA polymerase/reverse transcriptase
OrganismHepatitis B virus
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

DNA polymerase/reverse transcriptase shows approved-linked disease relevance led by chronic hepatitis B virus infection. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
chronic hepatitis B virus infection
9 linked drugs · 9 direct · 9 efficacy
Linked drugADEFOVIR
Linked drugADEFOVIR DIPIVOXIL
Linked drugELVUCITABINE
Linked drugENTECAVIR
Approved-linked Approved
hepatitis B virus infection
7 linked drugs · 7 direct · 7 efficacy
Linked drugADEFOVIR
Linked drugADEFOVIR DIPIVOXIL
Linked drugENTECAVIR
Linked drugLAMIVUDINE
Approved-linked Approved
HIV infection
7 linked drugs · 7 direct · 7 efficacy
Linked drugADEFOVIR
Linked drugADEFOVIR DIPIVOXIL
Linked drugELVUCITABINE
Linked drugLAMIVUDINE
Approved-linked Approved
hepatitis B virus infection
4 linked drugs · 4 direct · 4 efficacy
Linked drugENTECAVIR
Linked drugLAMIVUDINE
Linked drugTENOFOVIR DISOPROXIL MALEATE
Linked drugTENOFOVIR DISOPROXIL PHOSPHATE
Approved-linked Approved
viral disease
4 linked drugs · 4 direct · 4 efficacy
Linked drugADEFOVIR DIPIVOXIL
Linked drugENTECAVIR
Linked drugLAMIVUDINE
Linked drugTELBIVUDINE
Approved-linked Approved
infection
3 linked drugs · 3 direct · 3 efficacy
Linked drugENTECAVIR
Linked drugLAMIVUDINE
Linked drugTENOFOVIR ANHYDROUS
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with chronic hepatitis B virus infection because it currently carries approved-linked support. Linked drugs include ADEFOVIR, ADEFOVIR DIPIVOXIL, ELVUCITABINE, ENTECAVIR. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasechronic hepatitis B virus infection
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Source · ChEMBL 36 via Core Engine