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CHEMBL2362996 Target Snapshot

Voltage-gated potassium channel · PROTEIN FAMILY · Homo sapiens

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34Compounds
21Assays
0Approved Drugs
10.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Voltage-gated potassium channel shows approved-linked disease relevance led by multiple sclerosis. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P51787. Start with multiple sclerosis, then reuse UniProt P51787 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with multiple sclerosis, then reuse UniProt P51787 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 3 linked drugs
Open source guide
Disease program
multiple sclerosis

Voltage-gated potassium channel shows approved-linked disease relevance led by multiple sclerosis. 5 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.

Start review with multiple sclerosis because it currently carries approved-linked support. Linked drugs include AMIFAMPRIDINE, DALFAMPRIDINE, NERISPIRDINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 3 linked drugs
Open disease block
Protein anchor
Potassium voltage-gated channel subfamily KQT member 1

Potassium voltage-gated channel subfamily KQT member 1

Review this target as Voltage-gated potassium channel, mapped to UniProt P51787. ChEMBL maps the protein component as Potassium voltage-gated channel subfamily KQT member 1. Sequence length is 676 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt P51787 Protein 676 aa
Open protein block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Voltage-gated potassium channel as ChEMBL target CHEMBL2362996, mapped to UniProt P51787. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Voltage-gated potassium channel
PROTEIN FAMILY · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2362996
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P51787
Potassium voltage-gated channel subfamily KQT member 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Voltage-gated potassium channel is the right protein anchor across sources, using UniProt P51787 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why multiple sclerosis is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameVoltage-gated potassium channel
Target TypePROTEIN FAMILY
OrganismHomo sapiens
UniProtP51787
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPotassium voltage-gated channel subfamily KQT member 1
UniProt AccessionP51787
Component TypeProtein
Sequence Length676 aa

Potassium voltage-gated channel subfamily KQT member 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Voltage-gated potassium channel, mapped to UniProt P51787. ChEMBL maps the protein component as Potassium voltage-gated channel subfamily KQT member 1. Sequence length is 676 aa.

Mapped IDP51787
Review nameVoltage-gated potassium channel
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Voltage-gated potassium channel shows approved-linked disease relevance led by multiple sclerosis. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
multiple sclerosis
3 linked drugs · 3 direct · 3 efficacy
Linked drugAMIFAMPRIDINE
Linked drugDALFAMPRIDINE
Linked drugNERISPIRDINE
Approved-linked Approved
Myasthenia gravis
3 linked drugs · 3 direct · 3 efficacy
Linked drugAMIFAMPRIDINE
Linked drugAMIFAMPRIDINE PHOSPHATE
Linked drugGUANIDINE HYDROCHLORIDE
Approved-linked Approved
Lambert-Eaton myasthenic syndrome
2 linked drugs · 2 direct · 2 efficacy
Linked drugAMIFAMPRIDINE
Linked drugAMIFAMPRIDINE PHOSPHATE
Approved-linked Approved
autoimmune disorder of the nervous system
1 linked drug · 1 direct · 1 efficacy
Linked drugAMIFAMPRIDINE PHOSPHATE
Approved-linked Approved
Genetic neuromuscular junction disease
1 linked drug · 1 direct · 1 efficacy
Linked drugAMIFAMPRIDINE PHOSPHATE
Approved-linked Approved
immune system disease
1 linked drug · 1 direct · 1 efficacy
Linked drugAMIFAMPRIDINE PHOSPHATE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with multiple sclerosis because it currently carries approved-linked support. Linked drugs include AMIFAMPRIDINE, DALFAMPRIDINE, NERISPIRDINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasemultiple sclerosis
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Assay Mix

Activity Type Distribution

IC509.0
KI1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5722941 9.82 Ki 0.15 Preclinical
CHEMBL5722941 9.74 IC50 0.18 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
2
9.5
pChEMBL
Assay Landscape

Assay Landscape

21
Total Assays
7
Tested Compounds
2
Assay Types
Binding — 20 assays, 7 compounds
BAO Format Assays Compounds Avg pChEMBL
protein format 20 7 9.8
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine