Dihydrofolate reductase · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q920D2. Use UniProt Q920D2 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q920D2 as the stable identity anchor, then attach disease evidence before program review.
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt Q920D2. Sequence length is 187 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydrofolate reductase as ChEMBL target CHEMBL2363, mapped to UniProt Q920D2. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dihydrofolate reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q920D2 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydrofolate reductase |
| UniProt Accession | Q920D2 |
| Component Type | Protein |
| Sequence Length | 187 aa |
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt Q920D2. Sequence length is 187 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL449706 | 10.85 | Ki | 0.014 | Preclinical |
| CHEMBL34259 | 10.14 | Ki | 0.073 | Approved |
| CHEMBL264373 | 9.92 | Ki | 0.12 | Preclinical |
| CHEMBL190650 | 9.49 | IC50 | 0.32 | Preclinical |
| CHEMBL337603 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL461523 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL23977 | 9.24 | Ki | 0.58 | Preclinical |
| CHEMBL7492 | 9.0 | IC50 | 1.0 | Clinical |
| CHEMBL140940 | 8.89 | IC50 | 1.3 | Preclinical |
| CHEMBL3244854 | 8.82 | IC50 | 1.5 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 135 | 884 | 6.2 |
| single protein format | 16 | 112 | 6.2 |
| tissue-based format | 10 | 60 | 5.4 |
| organism-based format | 7 | 2 | 5.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 8.0 |
| tissue-based format | 1 | 1 | — |