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Target Snapshot

CHEMBL2364025 Target Snapshot

GABA-A receptor · PROTEIN COMPLEX GROUP · Pediculus humanus

0Compounds
0Assays
0Approved Drugs
0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

GABA-A receptor shows approved-linked disease relevance led by parasitic infection. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt E0W492. Start with parasitic infection, then reuse UniProt E0W492 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with parasitic infection, then reuse UniProt E0W492 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
parasitic infection

GABA-A receptor shows approved-linked disease relevance led by parasitic infection. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with parasitic infection because it currently carries approved-linked support. Linked drugs include LINDANE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats GABA-A receptor as ChEMBL target CHEMBL2364025, mapped to UniProt E0W492. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
GABA-A receptor
PROTEIN COMPLEX GROUP · Pediculus humanus
As of 2026-09-14
ChEMBL target ID
CHEMBL2364025
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
E0W492
Gaba-gated chloride channel, putative
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether GABA-A receptor is the right protein anchor across sources, using UniProt E0W492 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why parasitic infection is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGaba-gated chloride channel, putative
UniProt AccessionE0W492
Component TypeProtein
Sequence Length423 aa

Gaba-gated chloride channel, putative

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as GABA-A receptor, mapped to UniProt E0W492. ChEMBL maps the protein component as Gaba-gated chloride channel, putative. Sequence length is 423 aa.

Mapped IDE0W492
Review nameGABA-A receptor
OrganismPediculus humanus
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

GABA-A receptor shows approved-linked disease relevance led by parasitic infection. 1 more disease program remain visible in the same review block.

Approved-linked Approved
parasitic infection
1 linked drug · 1 direct · 1 efficacy
Linked drugLINDANE
Clinical signal Phase II
lice infestation
1 linked drug · 1 direct · 1 efficacy
Linked drugLINDANE
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with parasitic infection because it currently carries approved-linked support. Linked drugs include LINDANE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseparasitic infection
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Source · ChEMBL 36 via Core Engine