Dihydropteroate synthase · SINGLE PROTEIN · Bacteria
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Dihydropteroate synthase shows approved-linked disease relevance led by bacterial disease. 5 more disease programs remain visible in the same review block. 16 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P0AC13. Start with bacterial disease, then reuse UniProt P0AC13 as the stable protein anchor across project notes and exports.
Start with bacterial disease, then reuse UniProt P0AC13 as the stable protein anchor across project notes and exports.
Dihydropteroate synthase shows approved-linked disease relevance led by bacterial disease. 5 more disease programs remain visible in the same review block. 16 linked drugs remain visible in the same block.
Start review with bacterial disease because it currently carries approved-linked support. Linked drugs include CO-TRIMOXAZOLE, MAFENIDE ACETATE, SULFADIAZINE, SULFADIMETHOXINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyDihydropteroate synthase
Review this target as Dihydropteroate synthase, mapped to UniProt P0AC13. Sequence length is 282 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydropteroate synthase as ChEMBL target CHEMBL2364668, mapped to UniProt P0AC13. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Dihydropteroate synthase is the right protein anchor across sources, using UniProt P0AC13 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why bacterial disease is currently framed as approved-linked support. It currently carries 16 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Dihydropteroate synthase |
| Target Type | SINGLE PROTEIN |
| Organism | Bacteria |
| UniProt | P0AC13 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydropteroate synthase |
| UniProt Accession | P0AC13 |
| Component Type | Protein |
| Sequence Length | 282 aa |
Dihydropteroate synthase
Review this target as Dihydropteroate synthase, mapped to UniProt P0AC13. Sequence length is 282 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Dihydropteroate synthase shows approved-linked disease relevance led by bacterial disease. 5 more disease programs remain visible in the same review block.
Start review with bacterial disease because it currently carries approved-linked support. Linked drugs include CO-TRIMOXAZOLE, MAFENIDE ACETATE, SULFADIAZINE, SULFADIMETHOXINE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL159139 | 6.16 | IC50 | 700.0 | Preclinical |
| CHEMBL3233211 | 5.8 | Kd | 1600.0 | Preclinical |
| CHEMBL3233201 | 5.41 | Kd | 3900.0 | Preclinical |
| CHEMBL3233207 | 5.41 | Kd | 3900.0 | Preclinical |
| CHEMBL3359160 | 5.11 | Kd | 7800.0 | Preclinical |
| CHEMBL3233212 | 5.09 | Kd | 8200.0 | Preclinical |
| CHEMBL3359158 | 5.08 | Kd | 8400.0 | Preclinical |
| CHEMBL3359162 | 5.07 | Kd | 8500.0 | Preclinical |
| CHEMBL3359163 | 5.01 | Kd | 9740.0 | Preclinical |
| CHEMBL3233202 | 4.91 | Kd | 12300.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 13 | 5.1 |