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Target Snapshot

CHEMBL2364670 Target Snapshot

Beta-lactamase TEM · SINGLE PROTEIN · Bacteria

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167Compounds
12Assays
6Approved Drugs
116.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Beta-lactamase TEM shows approved-linked disease relevance led by infection. 5 more disease programs remain visible in the same review block. 4 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P62593. Start with infection, then reuse UniProt P62593 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with infection, then reuse UniProt P62593 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 4 linked drugs
Open source guide
Disease program
infection

Beta-lactamase TEM shows approved-linked disease relevance led by infection. 5 more disease programs remain visible in the same review block. 4 linked drugs remain visible in the same block.

Start review with infection because it currently carries approved-linked support. Linked drugs include AVIBACTAM SODIUM, RELEBACTAM, SULBACTAM SODIUM, TAZOBACTAM SODIUM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 4 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Beta-lactamase TEM as ChEMBL target CHEMBL2364670, mapped to UniProt P62593. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Beta-lactamase TEM
SINGLE PROTEIN · Bacteria
As of 2026-09-13
ChEMBL target ID
CHEMBL2364670
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P62593
Beta-lactamase TEM
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Beta-lactamase TEM is the right protein anchor across sources, using UniProt P62593 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why infection is currently framed as approved-linked support. It currently carries 4 linked drugs in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameBeta-lactamase TEM
Target TypeSINGLE PROTEIN
OrganismBacteria
UniProtP62593
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBeta-lactamase TEM
UniProt AccessionP62593
Component TypeProtein
Sequence Length286 aa

Beta-lactamase TEM

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Beta-lactamase TEM, mapped to UniProt P62593. Sequence length is 286 aa.

Mapped IDP62593
Review nameBeta-lactamase TEM
OrganismBacteria
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Beta-lactamase TEM shows approved-linked disease relevance led by infection. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
infection
4 linked drugs · 4 direct · 4 efficacy
Linked drugAVIBACTAM SODIUM
Linked drugRELEBACTAM
Linked drugSULBACTAM SODIUM
Linked drugTAZOBACTAM SODIUM
Approved-linked Approved
infection
4 linked drugs · 4 direct · 4 efficacy
Linked drugAVIBACTAM SODIUM
Linked drugCLAVULANATE POTASSIUM
Linked drugSULBACTAM SODIUM
Linked drugTAZOBACTAM SODIUM
Approved-linked Approved
urinary tract infection
4 linked drugs · 4 direct · 4 efficacy
Linked drugAVIBACTAM SODIUM
Linked drugCLAVULANATE POTASSIUM
Linked drugRELEBACTAM
Linked drugTAZOBACTAM SODIUM
Approved-linked Approved
pyelonephritis
3 linked drugs · 3 direct · 3 efficacy
Linked drugAVIBACTAM SODIUM
Linked drugCLAVULANATE POTASSIUM
Linked drugRELEBACTAM
Approved-linked Approved
pneumonia
2 linked drugs · 2 direct · 2 efficacy
Linked drugCLAVULANATE POTASSIUM
Linked drugTAZOBACTAM SODIUM
Approved-linked Approved
appendicitis
1 linked drug · 1 direct · 1 efficacy
Linked drugTAZOBACTAM SODIUM
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with infection because it currently carries approved-linked support. Linked drugs include AVIBACTAM SODIUM, RELEBACTAM, SULBACTAM SODIUM, TAZOBACTAM SODIUM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseinfection
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

6
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC5080.0
KI36.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4114803 9.7 IC50 0.2 Preclinical
CHEMBL4111477 9.4 IC50 0.4 Preclinical
CHEMBL4114749 8.85 IC50 1.4 Preclinical
CHEMBL4106598 8.74 IC50 1.8 Preclinical
CHEMBL1689063 8.72 IC50 1.9 Approved
CHEMBL4106976 8.62 IC50 2.4 Preclinical
CHEMBL4533632 8.52 IC50 3.0 Preclinical
CHEMBL4109897 8.46 IC50 3.5 Preclinical
CHEMBL4114669 8.38 IC50 4.2 Preclinical
CHEMBL4114818 8.04 IC50 9.2 Preclinical
Distribution

pChEMBL Value Distribution

19
5.0
10
5.5
7
6.0
4
6.5
8
7.0
6
7.5
3
8.0
7
8.5
1
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

AVIBACTAM
CHEMBL1689063
Approved 2015
Properties Compare Identifier
TAZOBACTAM
CHEMBL404
Approved 1993
Properties Compare Identifier
CLAVULANIC ACID
CHEMBL777
Approved 1984
Properties Compare Identifier
Assay Landscape

Assay Landscape

12
Total Assays
91
Tested Compounds
1
Assay Types
Binding — 12 assays, 91 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 6 85 6.0
single protein format 5 4 5.7
cell-based format 1 2 4.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine