Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL2364678 Target Snapshot

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI · SINGLE PROTEIN · Bacteria

0Compounds
0Assays
0Approved Drugs
0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI shows late clinical disease relevance led by allergic disease. 4 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P0AEK4. Start with allergic disease, then reuse UniProt P0AEK4 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with allergic disease, then reuse UniProt P0AEK4 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
allergic disease

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI shows late clinical disease relevance led by allergic disease. 4 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with allergic disease because it currently carries late clinical support. Linked drugs include TRICLOSAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Late clinical Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Enoyl-[acyl-carrier-protein] reductase [NADH] FabI as ChEMBL target CHEMBL2364678, mapped to UniProt P0AEK4. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
SINGLE PROTEIN · Bacteria
As of 2026-09-13
ChEMBL target ID
CHEMBL2364678
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P0AEK4
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Enoyl-[acyl-carrier-protein] reductase [NADH] FabI is the right protein anchor across sources, using UniProt P0AEK4 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why allergic disease is currently framed as late clinical support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelEnoyl-[acyl-carrier-protein] reductase [NADH] FabI
UniProt AccessionP0AEK4
Component TypeProtein
Sequence Length262 aa

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Enoyl-[acyl-carrier-protein] reductase [NADH] FabI, mapped to UniProt P0AEK4. Sequence length is 262 aa.

Mapped IDP0AEK4
Review nameEnoyl-[acyl-carrier-protein] reductase [NADH] FabI
OrganismBacteria
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Late clinical Open Targets-ready proxy

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI shows late clinical disease relevance led by allergic disease. 4 more disease programs remain visible in the same review block.

Late clinical Phase III
allergic disease
1 linked drug · 1 direct · 1 efficacy
Linked drugTRICLOSAN
Late clinical Phase III
gingivitis
1 linked drug · 1 direct · 1 efficacy
Linked drugTRICLOSAN
Late clinical Phase III
mucositis
1 linked drug · 1 direct · 1 efficacy
Linked drugTRICLOSAN
Late clinical Phase III
periodontal disorder
1 linked drug · 1 direct · 1 efficacy
Linked drugTRICLOSAN
Late clinical Phase III
periodontitis
1 linked drug · 1 direct · 1 efficacy
Linked drugTRICLOSAN
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with allergic disease because it currently carries late clinical support. Linked drugs include TRICLOSAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseallergic disease
Strongest levelLate clinical
Block modeOpen Targets-ready proxy
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Source · ChEMBL 36 via Core Engine