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Target Snapshot

CHEMBL2364683 Target Snapshot

Bacterial urease · PROTEIN COMPLEX · Bacteria

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32Compounds
2Assays
1Approved Drugs
32.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Bacterial urease shows approved-linked disease relevance led by urinary tract infection. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q03282. Start with urinary tract infection, then reuse UniProt Q03282 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with urinary tract infection, then reuse UniProt Q03282 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
urinary tract infection

Bacterial urease shows approved-linked disease relevance led by urinary tract infection. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with urinary tract infection because it currently carries approved-linked support. Linked drugs include ACETOHYDROXAMIC ACID. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Bacterial urease as ChEMBL target CHEMBL2364683, mapped to UniProt Q03282. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Bacterial urease
PROTEIN COMPLEX · Bacteria
As of 2026-09-13
ChEMBL target ID
CHEMBL2364683
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q03282
Urease subunit gamma
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Bacterial urease is the right protein anchor across sources, using UniProt Q03282 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why urinary tract infection is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameBacterial urease
Target TypePROTEIN COMPLEX
OrganismBacteria
UniProtQ03282
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelUrease subunit gamma
UniProt AccessionQ03282
Component TypeProtein
Sequence Length100 aa

Urease subunit gamma

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Bacterial urease, mapped to UniProt Q03282. ChEMBL maps the protein component as Urease subunit gamma. Sequence length is 100 aa.

Mapped IDQ03282
Review nameBacterial urease
OrganismBacteria
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Bacterial urease shows approved-linked disease relevance led by urinary tract infection. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
urinary tract infection
1 linked drug · 1 direct · 1 efficacy
Linked drugACETOHYDROXAMIC ACID
Clinical signal Phase I
argininosuccinic aciduria
1 linked drug · 1 direct · 1 efficacy
Linked drugACETOHYDROXAMIC ACID
Clinical signal Phase I
carbamoyl phosphate synthetase I deficiency disease
1 linked drug · 1 direct · 1 efficacy
Linked drugACETOHYDROXAMIC ACID
Clinical signal Phase I
citrullinemia
1 linked drug · 1 direct · 1 efficacy
Linked drugACETOHYDROXAMIC ACID
Clinical signal Phase I
ornithine carbamoyltransferase deficiency
1 linked drug · 1 direct · 1 efficacy
Linked drugACETOHYDROXAMIC ACID
Clinical signal Phase I
urea cycle disorder
1 linked drug · 1 direct · 1 efficacy
Linked drugACETOHYDROXAMIC ACID
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with urinary tract infection because it currently carries approved-linked support. Linked drugs include ACETOHYDROXAMIC ACID. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseurinary tract infection
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5032.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4437765 5.41 IC50 3900.0 Preclinical
CHEMBL4473387 5.3 IC50 4970.0 Preclinical
CHEMBL4441391 5.24 IC50 5700.0 Preclinical
CHEMBL4436232 4.86 IC50 13730.0 Preclinical
CHEMBL4587997 4.84 IC50 14510.0 Preclinical
CHEMBL4521852 4.79 IC50 16300.0 Preclinical
CHEMBL4446149 4.77 IC50 16910.0 Preclinical
CHEMBL4474805 4.75 IC50 17990.0 Preclinical
CHEMBL734 4.54 IC50 29200.0 Approved
CHEMBL4557719 4.51 IC50 31200.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
18
Tested Compounds
1
Assay Types
Binding — 2 assays, 18 compounds
BAO Format Assays Compounds Avg pChEMBL
protein complex format 2 18 4.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine