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Target Snapshot

CHEMBL2364705 Target Snapshot

Tubulin · PROTEIN COMPLEX GROUP · Nematoda

0Compounds
0Assays
0Approved Drugs
0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Tubulin shows approved-linked disease relevance led by Helminthiasis. 5 more disease programs remain visible in the same review block. 4 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt F1L5G6. Start with Helminthiasis, then reuse UniProt F1L5G6 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with Helminthiasis, then reuse UniProt F1L5G6 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 4 linked drugs
Open source guide
Disease program
Helminthiasis

Tubulin shows approved-linked disease relevance led by Helminthiasis. 5 more disease programs remain visible in the same review block. 4 linked drugs remain visible in the same block.

Start review with Helminthiasis because it currently carries approved-linked support. Linked drugs include ALBENDAZOLE, MEBENDAZOLE, OXFENDAZOLE, THIABENDAZOLE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 4 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Tubulin as ChEMBL target CHEMBL2364705, mapped to UniProt F1L5G6. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Tubulin
PROTEIN COMPLEX GROUP · Nematoda
As of 2026-09-13
ChEMBL target ID
CHEMBL2364705
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
F1L5G6
Tubulin alpha chain
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Tubulin is the right protein anchor across sources, using UniProt F1L5G6 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why Helminthiasis is currently framed as approved-linked support. It currently carries 4 linked drugs in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTubulin alpha chain
UniProt AccessionF1L5G6
Component TypeProtein
Sequence Length520 aa

Tubulin alpha chain

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Tubulin, mapped to UniProt F1L5G6. ChEMBL maps the protein component as Tubulin alpha chain. Sequence length is 520 aa.

Mapped IDF1L5G6
Review nameTubulin
OrganismNematoda
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Tubulin shows approved-linked disease relevance led by Helminthiasis. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
Helminthiasis
4 linked drugs · 4 direct · 4 efficacy
Linked drugALBENDAZOLE
Linked drugMEBENDAZOLE
Linked drugOXFENDAZOLE
Linked drugTHIABENDAZOLE
Approved-linked Approved
infection
2 linked drugs · 2 direct · 2 efficacy
Linked drugALBENDAZOLE
Linked drugOXFENDAZOLE
Approved-linked Approved
cysticercosis
1 linked drug · 1 direct · 1 efficacy
Linked drugALBENDAZOLE
Late clinical Phase III
filariasis
2 linked drugs · 2 direct · 2 efficacy
Linked drugALBENDAZOLE
Linked drugOXFENDAZOLE
Late clinical Phase III
anemia (phenotype)
1 linked drug · 1 direct · 1 efficacy
Linked drugMEBENDAZOLE
Late clinical Phase III
colorectal cancer
1 linked drug · 1 direct · 1 efficacy
Linked drugMEBENDAZOLE
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with Helminthiasis because it currently carries approved-linked support. Linked drugs include ALBENDAZOLE, MEBENDAZOLE, OXFENDAZOLE, THIABENDAZOLE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseHelminthiasis
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Source · ChEMBL 36 via Core Engine