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Target Snapshot

CHEMBL2366040 Target Snapshot

Globotriosylceramide · SMALL MOLECULE · Homo sapiens

0Compounds
0Assays
0Approved Drugs
0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Globotriosylceramide shows approved-linked disease relevance led by Fabry disease. 3 linked drugs keep the current disease frame grounded. Use Fabry disease as the disease frame, then confirm a stable protein accession before cross-source reuse.

Review focus
Disease frame ready

Use Fabry disease as the disease frame, then confirm a stable protein accession before cross-source reuse.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 3 linked drugs
Open source guide
Disease program
Fabry disease

Globotriosylceramide shows approved-linked disease relevance led by Fabry disease. 3 linked drugs remain visible in the same block.

Start review with Fabry disease because it currently carries approved-linked support. Linked drugs include AGALSIDASE ALFA, AGALSIDASE BETA, PEGUNIGALSIDASE ALFA. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 3 linked drugs
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Globotriosylceramide as ChEMBL target CHEMBL2366040. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Globotriosylceramide
SMALL MOLECULE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2366040
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Globotriosylceramide still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why Fabry disease is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGlobotriosylceramide
UniProt AccessionN/A

Globotriosylceramide

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Globotriosylceramide.

Review nameGlobotriosylceramide
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Globotriosylceramide shows approved-linked disease relevance led by Fabry disease.

Approved-linked Approved
Fabry disease
3 linked drugs · 3 direct · 3 efficacy
Linked drugAGALSIDASE ALFA
Linked drugAGALSIDASE BETA
Linked drugPEGUNIGALSIDASE ALFA
Source · ChEMBL drug mechanism + indication proxy
Review Cue

How to read disease relevance

Start review with Fabry disease because it currently carries approved-linked support. Linked drugs include AGALSIDASE ALFA, AGALSIDASE BETA, PEGUNIGALSIDASE ALFA. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseFabry disease
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Source · ChEMBL 36 via Core Engine