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Target Snapshot

CHEMBL2366066 Target Snapshot

LP-1 · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
136Compounds
37Assays
16Approved Drugs
113.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats LP-1 as ChEMBL target CHEMBL2366066. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
LP-1
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366066
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether LP-1 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameLP-1
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLP-1
UniProt AccessionN/A

LP-1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as LP-1.

Review nameLP-1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

16
Approved
6
Phase III
8
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50111.0
EC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1771376 8.52 IC50 3.0 Preclinical
CHEMBL96926 8.39 IC50 4.083 Preclinical
CHEMBL4460323 7.9 IC50 12.7 Preclinical
CHEMBL451887 7.64 IC50 22.7 Approved
CHEMBL2013119 7.52 IC50 30.0 Clinical
CHEMBL300389 7.28 IC50 52.09 Preclinical
CHEMBL1738758 7.23 IC50 59.0 Clinical
CHEMBL325041 7.21 IC50 61.28 Clinical
CHEMBL514499 7.2 IC50 62.53 Preclinical
CHEMBL1256459 7.05 IC50 89.38 Preclinical
Distribution

pChEMBL Value Distribution

16
5.0
9
5.5
6
6.0
8
6.5
5
7.0
3
7.5
1
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CARFILZOMIB
CHEMBL451887
Approved 2009
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
Assay Landscape

Assay Landscape

37
Total Assays
100
Tested Compounds
1
Assay Types
Functional — 37 assays, 100 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 37 100 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine