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Target Snapshot

CHEMBL2366067 Target Snapshot

SIMA · CELL-LINE · Homo sapiens

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90Compounds
5Assays
13Approved Drugs
88.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SIMA as ChEMBL target CHEMBL2366067. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SIMA
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366067
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SIMA still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSIMA
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSIMA
UniProt AccessionN/A

SIMA

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as SIMA.

Review nameSIMA
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

13
Approved
5
Phase III
7
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC5088.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL94657 7.72 IC50 19.08 Clinical
CHEMBL325041 7.63 IC50 23.38 Clinical
CHEMBL96926 7.42 IC50 38.44 Preclinical
CHEMBL553025 6.95 IC50 112.96 Approved
CHEMBL888 6.79 IC50 161.25 Approved
CHEMBL105 6.62 IC50 241.42 Approved
CHEMBL575448 6.47 IC50 340.69 Clinical
CHEMBL428647 6.46 IC50 345.81 Approved
CHEMBL53463 6.42 IC50 381.86 Approved
CHEMBL2107358 6.31 IC50 494.17 Clinical
Distribution

pChEMBL Value Distribution

9
5.0
7
5.5
8
6.0
3
6.5
1
7.0
2
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

5
Total Assays
86
Tested Compounds
1
Assay Types
Functional — 5 assays, 86 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 86 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine