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Target Snapshot

CHEMBL2366076 Target Snapshot

CP50-MEL-B · CELL-LINE · Homo sapiens

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96Compounds
1Assays
21Approved Drugs
97.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats CP50-MEL-B as ChEMBL target CHEMBL2366076. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
CP50-MEL-B
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366076
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether CP50-MEL-B still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCP50-MEL-B
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCP50-MEL-B
UniProt AccessionN/A

CP50-MEL-B

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as CP50-MEL-B.

Review nameCP50-MEL-B
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

21
Approved
10
Phase III
9
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC5097.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL507361 8.34 IC50 4.575 Clinical
CHEMBL3545252 8.16 IC50 6.929 Approved
CHEMBL1972860 8.06 IC50 8.626 Clinical
CHEMBL96926 7.96 IC50 11.1 Preclinical
CHEMBL159 7.88 IC50 13.12 Approved
CHEMBL94657 7.72 IC50 19.03 Clinical
CHEMBL3349342 7.67 IC50 21.54 Preclinical
CHEMBL109480 7.46 IC50 34.5 Clinical
CHEMBL553025 7.36 IC50 43.44 Approved
CHEMBL217354 7.16 IC50 69.59 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
4
5.5
4
6.0
3
6.5
8
7.0
4
7.5
3
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

SELUMETINIB
CHEMBL1614701
Approved 2020
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

1
Total Assays
96
Tested Compounds
1
Assay Types
Functional — 1 assays, 96 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 96 5.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine