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Target Snapshot

CHEMBL2366083 Target Snapshot

TT · CELL-LINE · Homo sapiens

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67Compounds
37Assays
10Approved Drugs
56.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats TT as ChEMBL target CHEMBL2366083. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
TT
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2366083
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether TT still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameTT
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTT
UniProt AccessionN/A

TT

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as TT.

Review nameTT
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

10
Approved
2
Phase III
3
Phase II
Assay Mix

Activity Type Distribution

IC5056.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1336 8.85 IC50 1.4 Approved
CHEMBL573339 8.66 IC50 2.2 Preclinical
CHEMBL449158 7.94 IC50 11.41 Clinical
CHEMBL4633483 7.43 IC50 37.4 Preclinical
CHEMBL535 7.4 IC50 40.0 Approved
CHEMBL1081312 7.3 IC50 50.0 Preclinical
CHEMBL3288854 7.16 IC50 70.0 Preclinical
CHEMBL96926 6.66 IC50 216.89 Preclinical
CHEMBL1233882 6.11 IC50 780.0 Preclinical
CHEMBL1241857 6.1 IC50 800.0 Preclinical
Distribution

pChEMBL Value Distribution

13
5.0
3
5.5
2
6.0
1
6.5
4
7.0
1
7.5
0
8.0
2
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

SUNITINIB
CHEMBL535
Approved 2006
Properties Compare Identifier
SORAFENIB
CHEMBL1336
Approved 2005
Properties Compare Identifier
Assay Landscape

Assay Landscape

37
Total Assays
56
Tested Compounds
1
Assay Types
Functional — 37 assays, 56 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 36 56 5.5
organism-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine