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Target Snapshot

CHEMBL2366084 Target Snapshot

MEG-01 · CELL-LINE · Homo sapiens

186Compounds
27Assays
35Approved Drugs
193.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats MEG-01 as ChEMBL target CHEMBL2366084. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
MEG-01
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2366084
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether MEG-01 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMEG-01
UniProt AccessionN/A

MEG-01

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as MEG-01.

Review nameMEG-01
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

35
Approved
11
Phase III
10
Phase II
6
Phase I
Assay Mix

Activity Type Distribution

IC50192.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL213100 10.79 IC50 0.01626 Preclinical
CHEMBL1171837 9.89 IC50 0.1276 Approved
CHEMBL888 8.9 IC50 1.266 Approved
CHEMBL94657 8.82 IC50 1.525 Clinical
CHEMBL325041 8.46 IC50 3.489 Clinical
CHEMBL255863 8.08 IC50 8.283 Approved
CHEMBL96926 7.97 IC50 10.78 Preclinical
CHEMBL288441 7.89 IC50 13.0 Approved
CHEMBL159 7.83 IC50 14.74 Approved
CHEMBL3545252 7.76 IC50 17.37 Approved
Distribution

pChEMBL Value Distribution

32
5.0
10
5.5
15
6.0
12
6.5
9
7.0
8
7.5
2
8.0
2
8.5
0
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

AXITINIB
CHEMBL1289926
Approved 2012
BOSUTINIB
CHEMBL288441
Approved 2012
PONATINIB
CHEMBL1171837
Approved 2012
CRIZOTINIB
CHEMBL601719
Approved 2011
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
NILOTINIB
CHEMBL255863
Approved 2007
GEFITINIB
CHEMBL939
Approved 2003
IMATINIB
CHEMBL941
Approved 2001
SIROLIMUS
CHEMBL413
Approved 1999
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
VINBLASTINE
CHEMBL159
Approved 1965
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

27
Total Assays
158
Tested Compounds
1
Assay Types
Functional — 27 assays, 158 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 27 158 5.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine