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Target Snapshot

CHEMBL2366114 Target Snapshot

YT · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
89Compounds
3Assays
14Approved Drugs
79.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats YT as ChEMBL target CHEMBL2366114. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
YT
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366114
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether YT still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameYT
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelYT
UniProt AccessionN/A

YT

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as YT.

Review nameYT
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

14
Approved
6
Phase III
7
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC5079.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL252164 7.93 IC50 11.79 Clinical
CHEMBL96926 7.88 IC50 13.1 Preclinical
CHEMBL94657 7.73 IC50 18.74 Clinical
CHEMBL512504 7.33 IC50 46.7 Preclinical
CHEMBL325041 7.21 IC50 61.8 Clinical
CHEMBL2107358 7.13 IC50 73.45 Clinical
CHEMBL5209242 7.12 IC50 75.4 Preclinical
CHEMBL4297623 6.99 IC50 103.1 Clinical
CHEMBL2165191 6.92 IC50 120.66 Clinical
CHEMBL585951 6.69 IC50 204.44 Preclinical
Distribution

pChEMBL Value Distribution

11
5.0
6
5.5
3
6.0
6
6.5
4
7.0
3
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
PONATINIB
CHEMBL1171837
Approved 2012
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
Assay Landscape

Assay Landscape

3
Total Assays
78
Tested Compounds
1
Assay Types
Functional — 3 assays, 78 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 78 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine