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Target Snapshot

CHEMBL2366116 Target Snapshot

ETK-1 · CELL-LINE · Homo sapiens

135Compounds
1Assays
32Approved Drugs
137.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats ETK-1 as ChEMBL target CHEMBL2366116. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
ETK-1
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2366116
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether ETK-1 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelETK-1
UniProt AccessionN/A

ETK-1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as ETK-1.

Review nameETK-1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

32
Approved
12
Phase III
12
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50137.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL96926 9.52 IC50 0.2991 Preclinical
CHEMBL1256459 9.51 IC50 0.3062 Preclinical
CHEMBL3545252 9.25 IC50 0.5581 Approved
CHEMBL94657 9.01 IC50 0.9788 Clinical
CHEMBL428647 8.82 IC50 1.521 Approved
CHEMBL413 8.55 IC50 2.824 Approved
CHEMBL325041 8.55 IC50 2.843 Clinical
CHEMBL159 8.24 IC50 5.788 Approved
CHEMBL553025 8.16 IC50 6.921 Approved
CHEMBL1879463 8.1 IC50 7.885 Clinical
Distribution

pChEMBL Value Distribution

19
5.0
16
5.5
9
6.0
3
6.5
6
7.0
7
7.5
4
8.0
3
8.5
2
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
PONATINIB
CHEMBL1171837
Approved 2012
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
DASATINIB
CHEMBL5416410
Approved 2006
GEFITINIB
CHEMBL939
Approved 2003
SIROLIMUS
CHEMBL413
Approved 1999
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

1
Total Assays
135
Tested Compounds
1
Assay Types
Functional — 1 assays, 135 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 135 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine