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Target Snapshot

CHEMBL2366117 Target Snapshot

ECC10 · CELL-LINE · Homo sapiens

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44Compounds
2Assays
14Approved Drugs
43.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats ECC10 as ChEMBL target CHEMBL2366117. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
ECC10
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366117
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether ECC10 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameECC10
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelECC10
UniProt AccessionN/A

ECC10

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as ECC10.

Review nameECC10
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

14
Approved
7
Phase III
4
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC5043.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL65 8.41 IC50 3.853 Preclinical
CHEMBL3545252 8.34 IC50 4.597 Approved
CHEMBL159 7.67 IC50 21.16 Approved
CHEMBL1879463 7.5 IC50 31.95 Clinical
CHEMBL443684 7.42 IC50 37.92 Clinical
CHEMBL603469 6.51 IC50 310.87 Clinical
CHEMBL189584 6.47 IC50 338.98 Preclinical
CHEMBL1801204 6.46 IC50 350.35 Preclinical
CHEMBL939 6.45 IC50 352.96 Approved
CHEMBL1201182 6.23 IC50 585.1 Approved
Distribution

pChEMBL Value Distribution

7
5.0
6
5.5
7
6.0
1
6.5
1
7.0
2
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
VORINOSTAT
CHEMBL98
Approved 2006
Properties Compare Identifier
GEFITINIB
CHEMBL939
Approved 2003
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

2
Total Assays
43
Tested Compounds
1
Assay Types
Functional — 2 assays, 43 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 43 5.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine