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Target Snapshot

CHEMBL2366136 Target Snapshot

LB1047-RCC · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
134Compounds
1Assays
32Approved Drugs
136.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats LB1047-RCC as ChEMBL target CHEMBL2366136. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
LB1047-RCC
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366136
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether LB1047-RCC still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameLB1047-RCC
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLB1047-RCC
UniProt AccessionN/A

LB1047-RCC

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as LB1047-RCC.

Review nameLB1047-RCC
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

32
Approved
13
Phase III
12
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC50136.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL888 9.57 IC50 0.2688 Approved
CHEMBL94657 8.7 IC50 1.998 Clinical
CHEMBL325041 8.59 IC50 2.566 Clinical
CHEMBL96926 8.15 IC50 7.047 Preclinical
CHEMBL65 8.1 IC50 7.897 Preclinical
CHEMBL3545252 8.05 IC50 8.803 Approved
CHEMBL5416410 8.01 IC50 9.887 Approved
CHEMBL1972860 7.97 IC50 10.75 Clinical
CHEMBL105 7.87 IC50 13.6 Approved
CHEMBL1256459 7.6 IC50 24.88 Preclinical
Distribution

pChEMBL Value Distribution

25
5.0
13
5.5
12
6.0
6
6.5
13
7.0
6
7.5
4
8.0
2
8.5
0
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
PALBOCICLIB
CHEMBL189963
Approved 2015
Properties Compare Identifier
PONATINIB
CHEMBL1171837
Approved 2012
Properties Compare Identifier
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
DASATINIB
CHEMBL5416410
Approved 2006
Properties Compare Identifier
GEFITINIB
CHEMBL939
Approved 2003
Properties Compare Identifier
SIROLIMUS
CHEMBL413
Approved 1999
Properties Compare Identifier
GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
CYTARABINE
CHEMBL803
Approved 1969
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

1
Total Assays
134
Tested Compounds
1
Assay Types
Functional — 1 assays, 134 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 134 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine