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Target Snapshot

CHEMBL2366142 Target Snapshot

HAL-01 · CELL-LINE · Homo sapiens

164Compounds
9Assays
28Approved Drugs
171.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HAL-01 as ChEMBL target CHEMBL2366142. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HAL-01
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366142
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HAL-01 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHAL-01
UniProt AccessionN/A

HAL-01

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as HAL-01.

Review nameHAL-01
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

28
Approved
13
Phase III
13
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50171.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL325041 8.93 IC50 1.182 Clinical
CHEMBL65 8.59 IC50 2.551 Preclinical
CHEMBL2107358 8.53 IC50 2.968 Clinical
CHEMBL94657 8.3 IC50 5.017 Clinical
CHEMBL888 8.09 IC50 8.195 Approved
CHEMBL105 7.8 IC50 15.73 Approved
CHEMBL34259 7.65 IC50 22.27 Approved
CHEMBL1879463 7.25 IC50 55.83 Clinical
CHEMBL300389 7.18 IC50 66.04 Preclinical
CHEMBL1256459 7.12 IC50 76.58 Preclinical
Distribution

pChEMBL Value Distribution

27
5.0
35
5.5
15
6.0
12
6.5
4
7.0
2
7.5
2
8.0
3
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PALBOCICLIB
CHEMBL189963
Approved 2015
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
VORINOSTAT
CHEMBL98
Approved 2006
GEFITINIB
CHEMBL939
Approved 2003
SIROLIMUS
CHEMBL413
Approved 1999
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
CYTARABINE
CHEMBL803
Approved 1969
VINBLASTINE
CHEMBL159
Approved 1965
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

9
Total Assays
158
Tested Compounds
1
Assay Types
Functional — 9 assays, 158 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 9 158 5.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine