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Target Snapshot

CHEMBL2366159 Target Snapshot

RS4-11 · CELL-LINE · Homo sapiens

960Compounds
334Assays
35Approved Drugs
806.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats RS4-11 as ChEMBL target CHEMBL2366159. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
RS4-11
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366159
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether RS4-11 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelRS4-11
UniProt AccessionN/A

RS4-11

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as RS4-11.

Review nameRS4-11
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

35
Approved
17
Phase III
18
Phase II
9
Phase I
Assay Mix

Activity Type Distribution

IC50713.0
EC5093.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4546160 10.7 IC50 0.02 Preclinical
CHEMBL4550750 10.7 IC50 0.02 Preclinical
CHEMBL4519362 10.6 IC50 0.025 Preclinical
CHEMBL4572428 10.49 IC50 0.032 Preclinical
CHEMBL5278610 10.49 IC50 0.032 Preclinical
CHEMBL4226142 10.43 IC50 0.037 Preclinical
CHEMBL4573649 10.42 IC50 0.038 Preclinical
CHEMBL4224883 10.29 IC50 0.051 Preclinical
CHEMBL4472522 10.29 IC50 0.051 Preclinical
CHEMBL4449128 10.09 IC50 0.081 Preclinical
Distribution

pChEMBL Value Distribution

87
5.0
58
5.5
79
6.0
64
6.5
73
7.0
50
7.5
71
8.0
38
8.5
25
9.0
7
9.5
pChEMBL
Approved Drugs

Approved Drugs

PACRITINIB
CHEMBL2035187
Approved 2022
MIDOSTAURIN
CHEMBL608533
Approved 2017
VENETOCLAX
CHEMBL3137309
Approved 2016
PALBOCICLIB
CHEMBL189963
Approved 2015
BOSUTINIB
CHEMBL288441
Approved 2012
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
VORINOSTAT
CHEMBL98
Approved 2006
GEFITINIB
CHEMBL939
Approved 2003
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
ETOPOSIDE
CHEMBL44657
Approved 1983
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
CYTARABINE
CHEMBL803
Approved 1969
VINBLASTINE
CHEMBL159
Approved 1965
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

334
Total Assays
613
Tested Compounds
2
Assay Types
Functional — 333 assays, 613 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 282 613 6.8
organism-based format 51 0
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine