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Target Snapshot

CHEMBL2366161 Target Snapshot

D-392MG · CELL-LINE · Homo sapiens

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111Compounds
1Assays
26Approved Drugs
112.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats D-392MG as ChEMBL target CHEMBL2366161. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
D-392MG
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2366161
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether D-392MG still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameD-392MG
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelD-392MG
UniProt AccessionN/A

D-392MG

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as D-392MG.

Review nameD-392MG
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

26
Approved
8
Phase III
9
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50112.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL325041 8.96 IC50 1.103 Clinical
CHEMBL65 7.75 IC50 17.73 Preclinical
CHEMBL159 7.72 IC50 18.86 Approved
CHEMBL3545252 7.68 IC50 20.68 Approved
CHEMBL252164 7.42 IC50 38.42 Clinical
CHEMBL553025 7.18 IC50 65.93 Approved
CHEMBL1972860 7.1 IC50 78.65 Clinical
CHEMBL1879463 6.97 IC50 107.54 Clinical
CHEMBL94657 6.94 IC50 115.01 Clinical
CHEMBL34259 6.8 IC50 158.09 Approved
Distribution

pChEMBL Value Distribution

12
5.0
8
5.5
7
6.0
7
6.5
3
7.0
3
7.5
0
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
PONATINIB
CHEMBL1171837
Approved 2012
Properties Compare Identifier
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
METHOTREXATE
CHEMBL34259
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

1
Total Assays
111
Tested Compounds
1
Assay Types
Functional — 1 assays, 111 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 111 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine