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Target Snapshot

CHEMBL2366168 Target Snapshot

RL95-2 · CELL-LINE · Homo sapiens

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70Compounds
18Assays
13Approved Drugs
67.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats RL95-2 as ChEMBL target CHEMBL2366168. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
RL95-2
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366168
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether RL95-2 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameRL95-2
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelRL95-2
UniProt AccessionN/A

RL95-2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as RL95-2.

Review nameRL95-2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

13
Approved
4
Phase III
4
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC5067.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL413 9.97 IC50 0.1073 Approved
CHEMBL428647 9.18 IC50 0.6681 Approved
CHEMBL1256459 8.49 IC50 3.201 Preclinical
CHEMBL325041 8.42 IC50 3.793 Clinical
CHEMBL553025 8.15 IC50 7.132 Approved
CHEMBL514499 7.95 IC50 11.29 Preclinical
CHEMBL513909 7.76 IC50 17.38 Clinical
CHEMBL379300 7.64 IC50 22.81 Preclinical
CHEMBL5416410 6.98 IC50 103.8 Approved
CHEMBL300389 6.75 IC50 176.57 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
11
5.5
12
6.0
3
6.5
0
7.0
3
7.5
3
8.0
0
8.5
1
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
DASATINIB
CHEMBL5416410
Approved 2006
Properties Compare Identifier
SIROLIMUS
CHEMBL413
Approved 1999
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
Assay Landscape

Assay Landscape

18
Total Assays
61
Tested Compounds
1
Assay Types
Functional — 18 assays, 61 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 18 61 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine