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Target Snapshot

CHEMBL2366179 Target Snapshot

GOTO · CELL-LINE · Homo sapiens

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168Compounds
3Assays
30Approved Drugs
172.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats GOTO as ChEMBL target CHEMBL2366179. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
GOTO
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2366179
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether GOTO still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameGOTO
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGOTO
UniProt AccessionN/A

GOTO

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as GOTO.

Review nameGOTO
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

30
Approved
13
Phase III
14
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50172.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL449897 10.6 IC50 0.0253 Preclinical
CHEMBL466909 10.59 IC50 0.0258 Preclinical
CHEMBL3143911 10.58 IC50 0.0263 Preclinical
CHEMBL468539 10.56 IC50 0.0278 Preclinical
CHEMBL466907 10.56 IC50 0.0278 Preclinical
CHEMBL511905 10.55 IC50 0.0281 Preclinical
CHEMBL466114 10.55 IC50 0.0284 Preclinical
CHEMBL513819 10.54 IC50 0.0291 Preclinical
CHEMBL468747 10.48 IC50 0.0329 Preclinical
CHEMBL466908 10.48 IC50 0.0329 Preclinical
Distribution

pChEMBL Value Distribution

16
5.0
9
5.5
12
6.0
6
6.5
4
7.0
5
7.5
19
8.0
6
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VORINOSTAT
CHEMBL98
Approved 2006
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
CYTARABINE
CHEMBL803
Approved 1969
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

3
Total Assays
168
Tested Compounds
1
Assay Types
Functional — 3 assays, 168 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 168 6.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine