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Target Snapshot

CHEMBL2366190 Target Snapshot

KY821 · CELL-LINE · Homo sapiens

118Compounds
1Assays
25Approved Drugs
119.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats KY821 as ChEMBL target CHEMBL2366190. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
KY821
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2366190
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether KY821 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelKY821
UniProt AccessionN/A

KY821

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as KY821.

Review nameKY821
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

25
Approved
10
Phase III
8
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50119.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL96926 9.2 IC50 0.636 Preclinical
CHEMBL159 8.43 IC50 3.69 Approved
CHEMBL3545252 8.26 IC50 5.509 Approved
CHEMBL65 8.09 IC50 8.123 Preclinical
CHEMBL514499 7.8 IC50 15.95 Preclinical
CHEMBL1173655 7.69 IC50 20.6 Approved
CHEMBL428647 7.57 IC50 26.97 Approved
CHEMBL443684 7.53 IC50 29.75 Clinical
CHEMBL507361 7.27 IC50 53.3 Clinical
CHEMBL513909 7.25 IC50 56.32 Clinical
Distribution

pChEMBL Value Distribution

8
5.0
9
5.5
12
6.0
8
6.5
4
7.0
4
7.5
3
8.0
0
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

SELUMETINIB
CHEMBL1614701
Approved 2020
PALBOCICLIB
CHEMBL189963
Approved 2015
AFATINIB
CHEMBL1173655
Approved 2013
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
VORINOSTAT
CHEMBL98
Approved 2006
GEFITINIB
CHEMBL939
Approved 2003
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

1
Total Assays
118
Tested Compounds
1
Assay Types
Functional — 1 assays, 118 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 118 5.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine