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Target Snapshot

CHEMBL2366200 Target Snapshot

SU-DHL-1 · CELL-LINE · Homo sapiens

151Compounds
32Assays
18Approved Drugs
146.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SU-DHL-1 as ChEMBL target CHEMBL2366200. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SU-DHL-1
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2366200
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SU-DHL-1 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSU-DHL-1
UniProt AccessionN/A

SU-DHL-1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as SU-DHL-1.

Review nameSU-DHL-1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

18
Approved
5
Phase III
6
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC50145.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1947135 9.0 IC50 1.0 Preclinical
CHEMBL509032 8.7 IC50 2.0 Preclinical
CHEMBL4168868 8.32 IC50 4.8 Preclinical
CHEMBL3286830 8.31 IC50 4.9 Approved
CHEMBL325041 8.14 IC50 7.238 Clinical
CHEMBL105 8.06 IC50 8.609 Approved
CHEMBL553025 8.03 IC50 9.451 Approved
CHEMBL601719 8.0 IC50 10.0 Approved
CHEMBL1946939 8.0 IC50 10.0 Preclinical
CHEMBL2403108 7.82 IC50 15.0 Approved
Distribution

pChEMBL Value Distribution

16
5.0
11
5.5
15
6.0
8
6.5
9
7.0
3
7.5
7
8.0
1
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ENTRECTINIB
CHEMBL1983268
Approved 2019
LORLATINIB
CHEMBL3286830
Approved 2018
CERITINIB
CHEMBL2403108
Approved 2014
PONATINIB
CHEMBL1171837
Approved 2012
CRIZOTINIB
CHEMBL601719
Approved 2011
GEMCITABINE
CHEMBL888
Approved 1996
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
ETOPOSIDE
CHEMBL44657
Approved 1983
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
Assay Landscape

Assay Landscape

32
Total Assays
110
Tested Compounds
2
Assay Types
Functional — 31 assays, 110 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 31 110 6.1
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine