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Target Snapshot

CHEMBL2366212 Target Snapshot

NB14 · CELL-LINE · Homo sapiens

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99Compounds
1Assays
23Approved Drugs
100.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NB14 as ChEMBL target CHEMBL2366212. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NB14
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2366212
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NB14 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNB14
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNB14
UniProt AccessionN/A

NB14

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NB14.

Review nameNB14
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

23
Approved
10
Phase III
8
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC50100.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3545252 9.59 IC50 0.26 Approved
CHEMBL65 9.04 IC50 0.9071 Preclinical
CHEMBL159 8.3 IC50 4.953 Approved
CHEMBL1972860 8.18 IC50 6.637 Clinical
CHEMBL325041 7.75 IC50 17.98 Clinical
CHEMBL603469 7.71 IC50 19.59 Clinical
CHEMBL2041933 7.21 IC50 61.36 Preclinical
CHEMBL34259 7.12 IC50 75.01 Approved
CHEMBL217354 7.12 IC50 76.45 Preclinical
CHEMBL1879463 7.05 IC50 88.3 Clinical
Distribution

pChEMBL Value Distribution

15
5.0
7
5.5
6
6.0
2
6.5
5
7.0
2
7.5
2
8.0
0
8.5
1
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

PALBOCICLIB
CHEMBL189963
Approved 2015
Properties Compare Identifier
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
VORINOSTAT
CHEMBL98
Approved 2006
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
CYTARABINE
CHEMBL803
Approved 1969
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
METHOTREXATE
CHEMBL34259
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

1
Total Assays
99
Tested Compounds
1
Assay Types
Functional — 1 assays, 99 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 99 5.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine