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Target Snapshot

CHEMBL2366224 Target Snapshot

COLO-800 · CELL-LINE · Homo sapiens

137Compounds
2Assays
26Approved Drugs
139.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats COLO-800 as ChEMBL target CHEMBL2366224. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
COLO-800
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2366224
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether COLO-800 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCOLO-800
UniProt AccessionN/A

COLO-800

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as COLO-800.

Review nameCOLO-800
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

26
Approved
11
Phase III
10
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC50139.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3545252 9.41 IC50 0.3877 Approved
CHEMBL65 9.37 IC50 0.4281 Preclinical
CHEMBL159 8.48 IC50 3.342 Approved
CHEMBL553025 7.77 IC50 16.95 Approved
CHEMBL325041 7.75 IC50 17.64 Clinical
CHEMBL1972860 7.52 IC50 29.92 Clinical
CHEMBL94657 7.49 IC50 32.53 Clinical
CHEMBL1879463 7.48 IC50 32.92 Clinical
CHEMBL888 7.39 IC50 40.56 Approved
CHEMBL96926 7.29 IC50 51.25 Preclinical
Distribution

pChEMBL Value Distribution

10
5.0
9
5.5
8
6.0
7
6.5
5
7.0
3
7.5
1
8.0
0
8.5
2
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

RUCAPARIB
CHEMBL1173055
Approved 2016
PALBOCICLIB
CHEMBL189963
Approved 2015
OLAPARIB
CHEMBL521686
Approved 2014
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
SIROLIMUS
CHEMBL413
Approved 1999
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
CYTARABINE
CHEMBL803
Approved 1969
VINBLASTINE
CHEMBL159
Approved 1965
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

2
Total Assays
137
Tested Compounds
1
Assay Types
Functional — 2 assays, 137 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 137 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine