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Target Snapshot

CHEMBL2366229 Target Snapshot

KINGS-1 · CELL-LINE · Homo sapiens

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137Compounds
2Assays
28Approved Drugs
139.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats KINGS-1 as ChEMBL target CHEMBL2366229. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
KINGS-1
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366229
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether KINGS-1 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameKINGS-1
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelKINGS-1
UniProt AccessionN/A

KINGS-1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as KINGS-1.

Review nameKINGS-1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

28
Approved
13
Phase III
12
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50139.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL325041 9.14 IC50 0.7215 Clinical
CHEMBL3545252 8.93 IC50 1.169 Approved
CHEMBL96926 8.12 IC50 7.588 Preclinical
CHEMBL159 8.03 IC50 9.324 Approved
CHEMBL428647 7.63 IC50 23.55 Approved
CHEMBL252164 7.61 IC50 24.33 Clinical
CHEMBL94657 7.46 IC50 34.69 Clinical
CHEMBL413 7.29 IC50 51.55 Approved
CHEMBL1256459 7.24 IC50 58.03 Preclinical
CHEMBL553025 7.14 IC50 72.65 Approved
Distribution

pChEMBL Value Distribution

14
5.0
9
5.5
9
6.0
9
6.5
5
7.0
2
7.5
2
8.0
1
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CRIZOTINIB
CHEMBL601719
Approved 2011
Properties Compare Identifier
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
DASATINIB
CHEMBL5416410
Approved 2006
Properties Compare Identifier
SIROLIMUS
CHEMBL413
Approved 1999
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
METHOTREXATE
CHEMBL34259
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

2
Total Assays
137
Tested Compounds
1
Assay Types
Functional — 2 assays, 137 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 137 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine