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Target Snapshot

CHEMBL2366236 Target Snapshot

LU-134-A · CELL-LINE · Homo sapiens

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127Compounds
1Assays
27Approved Drugs
128.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats LU-134-A as ChEMBL target CHEMBL2366236. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
LU-134-A
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2366236
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether LU-134-A still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameLU-134-A
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLU-134-A
UniProt AccessionN/A

LU-134-A

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as LU-134-A.

Review nameLU-134-A
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

27
Approved
11
Phase III
12
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC50128.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL65 9.23 IC50 0.5865 Preclinical
CHEMBL325041 8.13 IC50 7.385 Clinical
CHEMBL159 8.07 IC50 8.582 Approved
CHEMBL3545252 7.96 IC50 11.02 Approved
CHEMBL94657 7.8 IC50 15.75 Clinical
CHEMBL1201182 7.54 IC50 28.9 Approved
CHEMBL888 7.4 IC50 40.02 Approved
CHEMBL105 7.33 IC50 46.72 Approved
CHEMBL553025 7.33 IC50 47.22 Approved
CHEMBL428647 7.32 IC50 47.73 Approved
Distribution

pChEMBL Value Distribution

13
5.0
8
5.5
12
6.0
6
6.5
10
7.0
3
7.5
2
8.0
0
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
GEFITINIB
CHEMBL939
Approved 2003
Properties Compare Identifier
GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
ETOPOSIDE
CHEMBL44657
Approved 1983
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
METHOTREXATE
CHEMBL34259
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

1
Total Assays
127
Tested Compounds
1
Assay Types
Functional — 1 assays, 127 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 127 5.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine