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Target Snapshot

CHEMBL2366253 Target Snapshot

697 · CELL-LINE · Homo sapiens

188Compounds
14Assays
33Approved Drugs
191.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

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Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 697 as ChEMBL target CHEMBL2366253. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
697
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2366253
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label697
UniProt AccessionN/A

697

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as 697.

Review name697
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

33
Approved
13
Phase III
15
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC50158.0
EC5033.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL105 9.89 IC50 0.1283 Approved
CHEMBL96926 9.37 IC50 0.4253 Preclinical
CHEMBL428647 8.82 IC50 1.495 Approved
CHEMBL3545252 8.77 IC50 1.718 Approved
CHEMBL1201182 8.77 IC50 1.7 Approved
CHEMBL94657 8.75 IC50 1.781 Clinical
CHEMBL325041 8.7 IC50 1.988 Clinical
CHEMBL65 8.69 IC50 2.029 Preclinical
CHEMBL3326006 8.57 IC50 2.7 Preclinical
CHEMBL553025 8.37 IC50 4.228 Approved
Distribution

pChEMBL Value Distribution

25
5.0
14
5.5
20
6.0
12
6.5
5
7.0
11
7.5
7
8.0
7
8.5
1
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

GIVINOSTAT
CHEMBL1213492
Approved 2024
MIDOSTAURIN
CHEMBL608533
Approved 2017
PALBOCICLIB
CHEMBL189963
Approved 2015
BOSUTINIB
CHEMBL288441
Approved 2012
PONATINIB
CHEMBL1171837
Approved 2012
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
SUNITINIB
CHEMBL535
Approved 2006
VORINOSTAT
CHEMBL98
Approved 2006
DASATINIB
CHEMBL5416410
Approved 2006
SIROLIMUS
CHEMBL413
Approved 1999
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
ETOPOSIDE
CHEMBL44657
Approved 1983
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
CYTARABINE
CHEMBL803
Approved 1969
VINBLASTINE
CHEMBL159
Approved 1965
METHOTREXATE
CHEMBL34259
Approved 1953
Assay Landscape

Assay Landscape

14
Total Assays
140
Tested Compounds
2
Assay Types
Functional — 13 assays, 140 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 12 140 6.2
organism-based format 1 0
ADME — 1 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 6 6.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine