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Target Snapshot

CHEMBL2366276 Target Snapshot

NCI-H187 · CELL-LINE · Homo sapiens

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526Compounds
97Assays
13Approved Drugs
501.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NCI-H187 as ChEMBL target CHEMBL2366276. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NCI-H187
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366276
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NCI-H187 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNCI-H187
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNCI-H187
UniProt AccessionN/A

NCI-H187

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NCI-H187.

Review nameNCI-H187
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

13
Approved
8
Phase III
6
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC50496.0
EC505.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2325764 8.85 IC50 1.4 Preclinical
CHEMBL1771376 8.4 IC50 4.0 Preclinical
CHEMBL2325763 8.1 IC50 7.9 Preclinical
CHEMBL1098028 7.85 IC50 14.0 Preclinical
CHEMBL553025 7.85 IC50 14.02 Approved
CHEMBL1818859 7.7 IC50 20.0 Preclinical
CHEMBL514499 7.63 IC50 23.29 Preclinical
CHEMBL53463 7.52 IC50 30.0 Approved
CHEMBL443684 7.43 EC50 37.0 Clinical
CHEMBL443684 7.42 IC50 38.4 Clinical
Distribution

pChEMBL Value Distribution

40
5.0
41
5.5
24
6.0
17
6.5
11
7.0
5
7.5
2
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VENETOCLAX
CHEMBL3137309
Approved 2016
Properties Compare Identifier
SIROLIMUS
CHEMBL413
Approved 1999
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
ETOPOSIDE
CHEMBL44657
Approved 1983
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

97
Total Assays
255
Tested Compounds
1
Assay Types
Functional — 97 assays, 255 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 96 255 5.3
organism-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine