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Target Snapshot

CHEMBL2366295 Target Snapshot

BB49-HNC · CELL-LINE · Homo sapiens

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135Compounds
1Assays
28Approved Drugs
137.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats BB49-HNC as ChEMBL target CHEMBL2366295. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
BB49-HNC
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366295
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether BB49-HNC still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameBB49-HNC
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBB49-HNC
UniProt AccessionN/A

BB49-HNC

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as BB49-HNC.

Review nameBB49-HNC
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

28
Approved
12
Phase III
13
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50137.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL325041 9.19 IC50 0.6515 Clinical
CHEMBL3545252 8.67 IC50 2.119 Approved
CHEMBL220241 8.1 IC50 7.885 Preclinical
CHEMBL252164 7.97 IC50 10.77 Clinical
CHEMBL159 7.9 IC50 12.56 Approved
CHEMBL109480 7.37 IC50 42.43 Clinical
CHEMBL449158 7.27 IC50 53.5 Clinical
CHEMBL300389 7.02 IC50 96.31 Preclinical
CHEMBL65 6.92 IC50 120.28 Preclinical
CHEMBL1972860 6.9 IC50 125.58 Clinical
Distribution

pChEMBL Value Distribution

16
5.0
11
5.5
9
6.0
6
6.5
3
7.0
2
7.5
1
8.0
1
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
DASATINIB
CHEMBL5416410
Approved 2006
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

1
Total Assays
135
Tested Compounds
1
Assay Types
Functional — 1 assays, 135 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 135 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine