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Target Snapshot

CHEMBL2366296 Target Snapshot

LB373-MEL-D · CELL-LINE · Homo sapiens

115Compounds
1Assays
23Approved Drugs
117.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats LB373-MEL-D as ChEMBL target CHEMBL2366296. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
LB373-MEL-D
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366296
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether LB373-MEL-D still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLB373-MEL-D
UniProt AccessionN/A

LB373-MEL-D

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as LB373-MEL-D.

Review nameLB373-MEL-D
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

23
Approved
10
Phase III
10
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50117.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL325041 9.15 IC50 0.7 Clinical
CHEMBL3545252 7.96 IC50 10.94 Approved
CHEMBL1972860 7.83 IC50 14.67 Clinical
CHEMBL94657 7.74 IC50 18.13 Clinical
CHEMBL96926 7.54 IC50 29.07 Preclinical
CHEMBL428647 7.39 IC50 41.05 Approved
CHEMBL2107358 7.37 IC50 42.32 Clinical
CHEMBL553025 7.33 IC50 46.8 Approved
CHEMBL159 7.19 IC50 64.11 Approved
CHEMBL65 7.04 IC50 91.19 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
9
5.5
7
6.0
6
6.5
5
7.0
4
7.5
0
8.0
0
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DASATINIB
CHEMBL5416410
Approved 2006
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

1
Total Assays
115
Tested Compounds
1
Assay Types
Functional — 1 assays, 115 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 115 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine