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Target Snapshot

CHEMBL2366297 Target Snapshot

ES7 · CELL-LINE · Homo sapiens

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145Compounds
2Assays
31Approved Drugs
137.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats ES7 as ChEMBL target CHEMBL2366297. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
ES7
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2366297
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether ES7 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameES7
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelES7
UniProt AccessionN/A

ES7

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as ES7.

Review nameES7
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

31
Approved
12
Phase III
12
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50137.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL65 10.59 IC50 0.02543 Preclinical
CHEMBL3545252 9.41 IC50 0.3885 Approved
CHEMBL325041 9.12 IC50 0.7663 Clinical
CHEMBL1972860 8.45 IC50 3.592 Clinical
CHEMBL105 8.44 IC50 3.653 Approved
CHEMBL553025 8.41 IC50 3.856 Approved
CHEMBL159 8.24 IC50 5.753 Approved
CHEMBL94657 8.23 IC50 5.871 Clinical
CHEMBL2107358 8.07 IC50 8.457 Clinical
CHEMBL1879463 7.74 IC50 18.09 Clinical
Distribution

pChEMBL Value Distribution

10
5.0
11
5.5
10
6.0
6
6.5
4
7.0
3
7.5
6
8.0
0
8.5
2
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PALBOCICLIB
CHEMBL189963
Approved 2015
Properties Compare Identifier
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
ETOPOSIDE
CHEMBL44657
Approved 1983
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
CYTARABINE
CHEMBL803
Approved 1969
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
METHOTREXATE
CHEMBL34259
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

2
Total Assays
135
Tested Compounds
1
Assay Types
Functional — 2 assays, 135 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 135 5.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine