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Target Snapshot

CHEMBL2366307 Target Snapshot

EW-3 · CELL-LINE · Homo sapiens

117Compounds
1Assays
28Approved Drugs
118.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats EW-3 as ChEMBL target CHEMBL2366307. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
EW-3
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2366307
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether EW-3 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelEW-3
UniProt AccessionN/A

EW-3

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as EW-3.

Review nameEW-3
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

28
Approved
12
Phase III
10
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50118.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL65 9.5 IC50 0.3192 Preclinical
CHEMBL3545252 9.13 IC50 0.7448 Approved
CHEMBL325041 7.51 IC50 30.59 Clinical
CHEMBL573107 7.45 IC50 35.8 Preclinical
CHEMBL159 7.43 IC50 37.21 Approved
CHEMBL1972860 7.4 IC50 39.88 Clinical
CHEMBL1801204 7.39 IC50 40.56 Preclinical
CHEMBL939 7.34 IC50 46.04 Approved
CHEMBL1201182 7.31 IC50 49.17 Approved
CHEMBL105 7.21 IC50 61.95 Approved
Distribution

pChEMBL Value Distribution

17
5.0
8
5.5
9
6.0
12
6.5
9
7.0
1
7.5
0
8.0
0
8.5
1
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

PALBOCICLIB
CHEMBL189963
Approved 2015
BOSUTINIB
CHEMBL288441
Approved 2012
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
GEFITINIB
CHEMBL939
Approved 2003
GEMCITABINE
CHEMBL888
Approved 1996
DOCETAXEL
CHEMBL3545252
Approved 1995
VINORELBINE
CHEMBL553025
Approved 1994
PACLITAXEL
CHEMBL428647
Approved 1992
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
TRETINOIN
CHEMBL38
Approved 1971
CYTARABINE
CHEMBL803
Approved 1969
VINBLASTINE
CHEMBL159
Approved 1965
Assay Landscape

Assay Landscape

1
Total Assays
117
Tested Compounds
1
Assay Types
Functional — 1 assays, 117 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 117 5.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine