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Target Snapshot

CHEMBL2366329 Target Snapshot

COR-L88 · CELL-LINE · Homo sapiens

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122Compounds
3Assays
24Approved Drugs
123.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats COR-L88 as ChEMBL target CHEMBL2366329. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
COR-L88
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366329
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether COR-L88 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCOR-L88
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCOR-L88
UniProt AccessionN/A

COR-L88

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as COR-L88.

Review nameCOR-L88
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

24
Approved
12
Phase III
8
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50123.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL325041 8.46 IC50 3.475 Clinical
CHEMBL3545252 7.69 IC50 20.54 Approved
CHEMBL159 7.61 IC50 24.32 Approved
CHEMBL553025 7.46 IC50 34.82 Approved
CHEMBL65 7.39 IC50 40.93 Preclinical
CHEMBL109480 7.31 IC50 49.12 Clinical
CHEMBL428647 7.23 IC50 59.27 Approved
CHEMBL514499 7.11 IC50 78.36 Preclinical
CHEMBL94657 6.92 IC50 118.98 Clinical
CHEMBL513909 6.83 IC50 148.02 Clinical
Distribution

pChEMBL Value Distribution

10
5.0
7
5.5
11
6.0
6
6.5
5
7.0
2
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

AFATINIB
CHEMBL1173655
Approved 2013
Properties Compare Identifier
GEFITINIB
CHEMBL939
Approved 2003
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

3
Total Assays
121
Tested Compounds
1
Assay Types
Functional — 3 assays, 121 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 121 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine