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Target Snapshot

CHEMBL2366336 Target Snapshot

D-566MG · CELL-LINE · Homo sapiens

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60Compounds
1Assays
17Approved Drugs
60.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats D-566MG as ChEMBL target CHEMBL2366336. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
D-566MG
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2366336
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether D-566MG still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameD-566MG
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelD-566MG
UniProt AccessionN/A

D-566MG

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as D-566MG.

Review nameD-566MG
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

17
Approved
6
Phase III
7
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC5060.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL65 9.88 IC50 0.1315 Preclinical
CHEMBL3545252 9.74 IC50 0.1823 Approved
CHEMBL159 8.69 IC50 2.043 Approved
CHEMBL109480 8.41 IC50 3.904 Clinical
CHEMBL1201182 8.14 IC50 7.157 Approved
CHEMBL1972860 7.82 IC50 15.23 Clinical
CHEMBL1879463 7.75 IC50 17.69 Clinical
CHEMBL603469 7.02 IC50 96.46 Clinical
CHEMBL217354 6.94 IC50 115.75 Preclinical
CHEMBL2041933 6.83 IC50 146.9 Preclinical
Distribution

pChEMBL Value Distribution

9
5.0
10
5.5
1
6.0
3
6.5
1
7.0
2
7.5
2
8.0
1
8.5
0
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
VORINOSTAT
CHEMBL98
Approved 2006
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
CYTARABINE
CHEMBL803
Approved 1969
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
Assay Landscape

Assay Landscape

1
Total Assays
60
Tested Compounds
1
Assay Types
Functional — 1 assays, 60 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 60 5.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine