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Target Snapshot

CHEMBL2366342 Target Snapshot

NCI-H524 · CELL-LINE · Homo sapiens

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102Compounds
7Assays
12Approved Drugs
121.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NCI-H524 as ChEMBL target CHEMBL2366342. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NCI-H524
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2366342
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NCI-H524 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNCI-H524
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNCI-H524
UniProt AccessionN/A

NCI-H524

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NCI-H524.

Review nameNCI-H524
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

12
Approved
5
Phase III
5
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50121.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1201748 9.59 IC50 0.26 Approved
CHEMBL3688339 8.72 IC50 1.9 Preclinical
CHEMBL5078321 8.47 IC50 3.36 Preclinical
CHEMBL2103835 8.43 IC50 3.7 Preclinical
CHEMBL4575530 8.15 IC50 7.0 Preclinical
CHEMBL4584764 8.1 IC50 8.0 Preclinical
CHEMBL4527856 8.0 IC50 10.0 Preclinical
CHEMBL4592483 8.0 IC50 10.0 Preclinical
CHEMBL4563412 7.96 IC50 11.0 Preclinical
CHEMBL4550617 7.82 IC50 15.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
11
5.5
15
6.0
9
6.5
9
7.0
8
7.5
6
8.0
1
8.5
0
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

CABAZITAXEL
CHEMBL1201748
Approved 2010
Properties Compare Identifier
SIROLIMUS
CHEMBL413
Approved 1999
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
Assay Landscape

Assay Landscape

7
Total Assays
100
Tested Compounds
1
Assay Types
Functional — 7 assays, 100 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 7 100 6.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine