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Target Snapshot

CHEMBL2366364 Target Snapshot

EW-1 · CELL-LINE · Homo sapiens

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135Compounds
1Assays
29Approved Drugs
137.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats EW-1 as ChEMBL target CHEMBL2366364. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
EW-1
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL2366364
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether EW-1 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameEW-1
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelEW-1
UniProt AccessionN/A

EW-1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as EW-1.

Review nameEW-1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

29
Approved
12
Phase III
12
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50137.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL65 8.75 IC50 1.777 Preclinical
CHEMBL94657 8.72 IC50 1.903 Clinical
CHEMBL413 8.66 IC50 2.172 Approved
CHEMBL888 8.65 IC50 2.223 Approved
CHEMBL3545252 8.53 IC50 2.982 Approved
CHEMBL159 8.5 IC50 3.148 Approved
CHEMBL428647 8.43 IC50 3.714 Approved
CHEMBL96926 8.41 IC50 3.882 Preclinical
CHEMBL553025 8.4 IC50 3.934 Approved
CHEMBL575448 8.4 IC50 3.998 Clinical
Distribution

pChEMBL Value Distribution

13
5.0
11
5.5
6
6.0
10
6.5
5
7.0
2
7.5
8
8.0
6
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
TEMSIROLIMUS
CHEMBL1201182
Approved 2007
Properties Compare Identifier
VORINOSTAT
CHEMBL98
Approved 2006
Properties Compare Identifier
SIROLIMUS
CHEMBL413
Approved 1999
Properties Compare Identifier
GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
DOCETAXEL
CHEMBL3545252
Approved 1995
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
CYTARABINE
CHEMBL803
Approved 1969
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
METHOTREXATE
CHEMBL34259
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

1
Total Assays
135
Tested Compounds
1
Assay Types
Functional — 1 assays, 135 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 135 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine