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Target Snapshot

CHEMBL2366461 Target Snapshot

Cytochrome b6-f complex subunit 4 · SINGLE PROTEIN · Spinacia oleracea

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103Compounds
9Assays
0Approved Drugs
161.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-15

Protein identity stays anchored to UniProt P00166. Use UniProt P00166 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P00166 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-15
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cytochrome b6-f complex subunit 4 as ChEMBL target CHEMBL2366461, mapped to UniProt P00166. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cytochrome b6-f complex subunit 4
SINGLE PROTEIN · Spinacia oleracea
As of 2026-09-15
ChEMBL target ID
CHEMBL2366461
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-15
www.ebi.ac.uk
UniProt accession
P00166
Cytochrome b6-f complex subunit 4
UniProt accession via ChEMBL component mapping As of 2026-09-15
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-15
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cytochrome b6-f complex subunit 4 is the right protein anchor across sources, using UniProt P00166 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCytochrome b6-f complex subunit 4
Target TypeSINGLE PROTEIN
OrganismSpinacia oleracea
UniProtP00166
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCytochrome b6-f complex subunit 4
UniProt AccessionP00166
Component TypeProtein
Sequence Length160 aa

Cytochrome b6-f complex subunit 4

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Cytochrome b6-f complex subunit 4, mapped to UniProt P00166. Sequence length is 160 aa.

Mapped IDP00166
Review nameCytochrome b6-f complex subunit 4
OrganismSpinacia oleracea
Assay Mix

Activity Type Distribution

IC50161.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2269225 7.29 IC50 51.29 Preclinical
CHEMBL2269217 7.21 IC50 61.66 Preclinical
CHEMBL2271285 7.18 IC50 66.07 Preclinical
CHEMBL2269224 7.16 IC50 69.18 Preclinical
CHEMBL2269222 7.02 IC50 95.5 Preclinical
CHEMBL2271292 7.01 IC50 97.72 Preclinical
CHEMBL2269218 6.98 IC50 104.71 Preclinical
CHEMBL2269214 6.94 IC50 114.82 Preclinical
CHEMBL2270230 6.94 IC50 114.82 Preclinical
CHEMBL1888800 6.93 IC50 117.49 Preclinical
Distribution

pChEMBL Value Distribution

10
5.0
9
5.5
12
6.0
35
6.5
9
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

9
Total Assays
83
Tested Compounds
1
Assay Types
Binding — 9 assays, 83 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 7 62 6.2
assay format 2 21 4.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine