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Target Snapshot

CHEMBL2367389 Target Snapshot

Whole blood · TISSUE · Homo sapiens

305Compounds
62Assays
1Approved Drugs
102.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Whole blood as ChEMBL target CHEMBL2367389. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Whole blood
TISSUE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2367389
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Whole blood still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelWhole blood
UniProt AccessionN/A

Whole blood

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Whole blood.

Review nameWhole blood
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
3
Phase II
Assay Mix

Activity Type Distribution

IC50101.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3288029 9.5 IC50 0.3162 Preclinical
CHEMBL570015 9.5 IC50 0.3162 Clinical
CHEMBL3221863 7.96 IC50 11.0 Preclinical
CHEMBL3586208 7.92 IC50 12.0 Preclinical
CHEMBL3288030 7.9 IC50 12.59 Preclinical
CHEMBL3221864 7.89 IC50 13.0 Preclinical
CHEMBL3220550 7.54 IC50 28.8 Preclinical
CHEMBL3220549 7.24 IC50 57.5 Preclinical
CHEMBL489100 7.22 IC50 60.0 Preclinical
CHEMBL3586210 7.21 IC50 62.0 Preclinical
Distribution

pChEMBL Value Distribution

9
5.0
13
5.5
14
6.0
23
6.5
7
7.0
5
7.5
0
8.0
0
8.5
0
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

BETAMETHASONE
CHEMBL632
Approved 1961
Assay Landscape

Assay Landscape

62
Total Assays
78
Tested Compounds
2
Assay Types
ADME — 37 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 20 0
tissue-based format 17 0
Functional — 25 assays, 78 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 21 78 6.4
cell-based format 4 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine