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Target Snapshot

CHEMBL2367449 Target Snapshot

Thoracic aorta · TISSUE · Rattus norvegicus

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464Compounds
138Assays
3Approved Drugs
418.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Thoracic aorta as ChEMBL target CHEMBL2367449. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Thoracic aorta
TISSUE · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL2367449
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Thoracic aorta still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameThoracic aorta
Target TypeTISSUE
OrganismRattus norvegicus
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelThoracic aorta
UniProt AccessionN/A

Thoracic aorta

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Thoracic aorta.

Review nameThoracic aorta
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

3
Approved
1
Phase III
2
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50112.0
EC50306.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4635150 8.85 EC50 1.413 Preclinical
CHEMBL4638745 8.68 EC50 2.089 Preclinical
CHEMBL4642313 8.47 EC50 3.388 Preclinical
CHEMBL3104471 8.16 EC50 6.918 Preclinical
CHEMBL4633010 8.12 EC50 7.586 Preclinical
CHEMBL4635281 8.08 EC50 8.4 Preclinical
CHEMBL4634858 8.07 EC50 8.5 Preclinical
CHEMBL4633684 8.05 EC50 9.0 Preclinical
CHEMBL559147 8.02 EC50 9.5 Preclinical
CHEMBL4643905 7.55 EC50 28.18 Preclinical
Distribution

pChEMBL Value Distribution

38
5.0
10
5.5
7
6.0
7
6.5
12
7.0
5
7.5
9
8.0
3
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PINACIDIL ANHYDROUS
CHEMBL1159
Approved 1989
Properties Compare Identifier
VERAPAMIL
CHEMBL6966
Approved 1981
Properties Compare Identifier
Assay Landscape

Assay Landscape

138
Total Assays
254
Tested Compounds
1
Assay Types
Functional — 138 assays, 254 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 133 236 5.3
assay format 5 18 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine