Catechol O-methyltransferase · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P22734. Use UniProt P22734 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P22734 as the stable identity anchor, then attach disease evidence before program review.
Catechol O-methyltransferase
Review this target as Catechol O-methyltransferase, mapped to UniProt P22734. Sequence length is 264 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Catechol O-methyltransferase as ChEMBL target CHEMBL2372, mapped to UniProt P22734. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Catechol O-methyltransferase |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P22734 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Catechol O-methyltransferase |
| UniProt Accession | P22734 |
| Component Type | Protein |
| Sequence Length | 264 aa |
Catechol O-methyltransferase
Review this target as Catechol O-methyltransferase, mapped to UniProt P22734. Sequence length is 264 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4463709 | 9.08 | IC50 | 0.84 | Preclinical |
| CHEMBL1324 | 9.04 | IC50 | 0.91 | Approved |
| CHEMBL1089318 | 8.82 | Ki | 1.5 | Approved |
| CHEMBL4437043 | 8.79 | IC50 | 1.64 | Preclinical |
| CHEMBL4447349 | 8.73 | IC50 | 1.862 | Preclinical |
| CHEMBL265218 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL953 | 8.52 | IC50 | 3.02 | Approved |
| CHEMBL4448310 | 8.5 | IC50 | 3.14 | Preclinical |
| CHEMBL160038 | 8.43 | IC50 | 3.7 | Clinical |
| CHEMBL4543735 | 8.43 | IC50 | 3.715 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 52 | 90 | 6.4 |
| organism-based format | 16 | 0 | — |
| single protein format | 14 | 7 | 7.7 |
| tissue-based format | 13 | 26 | 7.1 |
| cell-based format | 2 | 2 | 5.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 7 | 0 | — |
| assay format | 5 | 0 | — |
| cell-based format | 3 | 0 | — |
| single protein format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 10 | 0 | — |