Calpain-2 catalytic subunit · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P17655. Use UniProt P17655 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P17655 as the stable identity anchor, then attach disease evidence before program review.
Calpain-2 catalytic subunit
Review this target as Calpain-2 catalytic subunit, mapped to UniProt P17655. Sequence length is 700 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Calpain-2 catalytic subunit as ChEMBL target CHEMBL2382, mapped to UniProt P17655. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Calpain-2 catalytic subunit is the right protein anchor across sources, using UniProt P17655 as the stable mapping.
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| Preferred Name | Calpain-2 catalytic subunit |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P17655 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Calpain-2 catalytic subunit |
| UniProt Accession | P17655 |
| Component Type | Protein |
| Sequence Length | 700 aa |
Calpain-2 catalytic subunit
Review this target as Calpain-2 catalytic subunit, mapped to UniProt P17655. Sequence length is 700 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL315636 | 8.3 | Ki | 5.0 | Preclinical |
| CHEMBL91991 | 8.3 | Ki | 5.0 | Preclinical |
| CHEMBL117023 | 8.24 | Ki | 5.7 | Preclinical |
| CHEMBL89766 | 8.15 | Ki | 7.0 | Preclinical |
| CHEMBL92114 | 8.15 | Ki | 7.0 | Preclinical |
| CHEMBL89008 | 8.05 | Ki | 9.0 | Preclinical |
| CHEMBL88895 | 7.96 | Ki | 11.0 | Preclinical |
| CHEMBL88646 | 7.89 | Ki | 13.0 | Preclinical |
| CHEMBL130506 | 7.82 | Ki | 15.0 | Preclinical |
| CHEMBL130114 | 7.77 | Ki | 17.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 18 | 162 | 6.7 |
| assay format | 2 | 3 | 7.2 |
| tissue-based format | 1 | 2 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 3 | 7.1 |