Review anchor
Dihydroorotate dehydrogenase (quinone), mitochondrial
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
Evidence Snapshot
Dihydroorotate dehydrogenase (quinone), mitochondrial
CHEMBL2383
SINGLE PROTEIN
Rattus norvegicus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydroorotate dehydrogenase (quinone), mitochondrial as ChEMBL target CHEMBL2383, mapped to UniProt Q63707. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL2383
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q63707
Dihydroorotate dehydrogenase (quinone), mitochondrial
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Dihydroorotate dehydrogenase (quinone), mitochondrial matters
Dihydroorotate dehydrogenase (quinone), mitochondrial is reviewed as Dihydroorotate dehydrogenase (quinone), mitochondrial (UniProt Q63707); the current evidence base includes 3 approved drugs, 140 compounds, and 19 assays, with lead potency reaching pChEMBL 8.5.
Protein context
Dihydroorotate dehydrogenase (quinone), mitochondrial
Dihydroorotate dehydrogenase (quinone), mitochondrial Sequence length is 395 aa.
Review this target as Dihydroorotate dehydrogenase (quinone), mitochondrial, mapped to UniProt Q63707. Sequence length is 395 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt Q63707
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 3 approved drugs, 140 compounds, and 19 assays for this target. The dominant activity type is IC50. CHEMBL356115 is the current potency anchor at pChEMBL 8.5.
Use CHEMBL356115 as the tractability anchor when discussing potency (pChEMBL 8.5).
Activity source · ChEMBL 36 via Core Engine
3 approved
pChEMBL 8.5
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
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Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Dihydroorotate dehydrogenase (quinone), mitochondrial matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q63707, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
140
Total Compounds
19
Total Assays
3
Approved Drugs
IC50: 131.0, KD: 4.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL356115
|
8.5 | IC50 | — |
|
|
No preferred name
CHEMBL141248
|
8.3 | IC50 | — |
|
|
No preferred name
CHEMBL344913
|
8.3 | IC50 | — |
|
|
No preferred name
CHEMBL960
|
8.1 | IC50 | Approved |
|
|
No preferred name
CHEMBL973
|
8.1 | IC50 | Approved |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
TERIFLUNOMIDE
CHEMBL973
|
2012 |
|
|
LEFLUNOMIDE
CHEMBL960
|
1998 |
|
|
ATOVAQUONE
CHEMBL1450
|
1992 |
Source Header