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Target Snapshot

CHEMBL2384898 Target Snapshot

N-arachidonyl glycine receptor · SINGLE PROTEIN · Homo sapiens

213Compounds
39Assays
3Approved Drugs
286.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q14330. Use UniProt Q14330 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q14330 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats N-arachidonyl glycine receptor as ChEMBL target CHEMBL2384898, mapped to UniProt Q14330. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
N-arachidonyl glycine receptor
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL2384898
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q14330
N-arachidonyl glycine receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether N-arachidonyl glycine receptor is the right protein anchor across sources, using UniProt Q14330 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelN-arachidonyl glycine receptor
UniProt AccessionQ14330
Component TypeProtein
Sequence Length331 aa

N-arachidonyl glycine receptor

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as N-arachidonyl glycine receptor, mapped to UniProt Q14330. Sequence length is 331 aa.

Mapped IDQ14330
Review nameN-arachidonyl glycine receptor
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC50151.0
EC50134.0
KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5517636 8.0 EC50 10.0 Preclinical
CHEMBL5556102 7.72 EC50 19.0 Preclinical
CHEMBL161343 7.7 EC50 20.0 Preclinical
CHEMBL5557729 7.62 EC50 24.0 Preclinical
CHEMBL5556617 7.38 EC50 42.0 Preclinical
CHEMBL5558124 7.27 EC50 54.0 Preclinical
CHEMBL5556677 7.22 EC50 60.0 Preclinical
CHEMBL5532256 7.19 EC50 64.0 Preclinical
CHEMBL5512594 7.15 EC50 71.0 Preclinical
CHEMBL5555231 7.14 EC50 72.0 Preclinical
Distribution

pChEMBL Value Distribution

28
5.0
13
5.5
17
6.0
24
6.5
11
7.0
3
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DRONABINOL
CHEMBL465
Approved 1985
Assay Landscape

Assay Landscape

39
Total Assays
71
Tested Compounds
2
Assay Types
Binding — 22 assays, 26 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 20 26 5.3
single protein format 2 0
Functional — 17 assays, 71 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 16 71 6.4
assay format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine